Guidelines for monitoring of vancomycin serum concentrations in adult patients. Adult vancomycin dosing guidelines definitions total body weight tbw o patients actual weight. Vancomycin dosing and monitoring for patients with endstage renal disease receiving intermittent hemodialysis. Continuous infusion protocol introduction vancomycin has traditionally been dosed as intermittent boluses. Vancomycin resistant enterococci vre acteria, such as enterococcus, are commonly found in the bowel large intestine and generally do not cause any problems.
Vancomycin protocol rqhr hemodialysis renal function scribd. Vancomycin dosing and monitoring for pediatric patients. Dec 27, 2019 parenteral administration of vancomycin is not effective for treatment of staphylococcal enterocolitis and c. Prolonged and low exposure of vancomycin can select out resistant mutants and maintaining the sufficient concentrations throughout the dosing interval may prevent resistance. Vancomycin monitoring and dosing guideline alberta health. The aim of our work was to develop and validate a reliable lcmsmsbased measurement procedure for the quantification of vancomycin in serum, to be applied in the context of efforts. Guidelines for the use of vancomycin by continuous infusion. Pdf consensus guidelines recommend vancomycin doses of 15 to 20 mgkg every 8 to 12 hours in patients with normal renal function. Vancomycin dosing for adults university health system necessary patient information for dosing actual body weight the use of actual body weight is recommend for vancomycin dosing crcl vancomycin is almost exclusively renally cleared and must be renally adjusted o crcl 140age x wt in kg x 0. Use guideline based vancomycin dosing and monitoring to maximize treatment success and reduce unnecessary plasma vancomycin levels and needless dosage changes. First determine the exact dose and then a reasonable one that might be used clinically. Therapeutic monitoring of vancomycin in adult patients. Empiric therapy in combination with meropenem for postneurosurgical cns infections.
Peakmic, peak serum concentration divided by the mic. Crcl vancomycin is almost exclusively renally cleared and must be renally adjusted. Per best practice standards vancomycin, gentamicin see procedure above. Vancomycin prescribing and therapeutic drug monitoring. There is significant variability in guideline recommendations for vancomycin dose and enema volume and whether a retention enema should be used. Vancomycin vancomycin monitoring parameters recommendations for vancomycin therapeutic drug monitoring tdm recommended tdm parameters recommendation optimal monitoring parameter trough serum vancomycin concentrations are the most accurate and practical method for monitoring efficacy. Vancomycin has bactericidal activity against aerobic and anaerobic gram positive organisms. As a result, vancomycin dosing must be individualized. Vancomycin diffuses well into most body tissues, but distribution to.
Protocol continuous ambulatory peritoneal dialysis capd freeline solo exchange procedure. Intermittent therapies administered through a peripheral catheter. It is also important to highlight that 34 of 37 peritonitis episodes. There have been a number of logistical and medical problems with the safe dosing and monitoring of vancomycin. I would like to inform prescribers of a new ppo pp625 to be used for initial dosing of vancomycin to ensure optimal dosing until a pharmacist. Another case report showed a modified version of the lin desensitization protocol that stretched the procedure out to days when the patient reported adverse events during the slow desensitization process. Pharmacists in the regina quappelle health region rqhr. Vancomycin monitoring and dosing guideline contact your local laboratory for hours of service or visit myhealth.
After this, vancomycin levels can be repeated every 3 days or whenever there is a significant change in bodyweight, serum creatinine or if the dose has been adjusted. Allow sufficient time for drug clearance before restarting next dose. Vancomycin is a glycopeptide antibiotic that needs to be dosed to achieve target trough levels of 1520 mgl. Pre and 3 hour post vancomycin level target 2040 mgl if calculation of precise kinetic parameters are necessary e. Do not restart vancomycin until the randomtrough level is estimated or confirmed to be atnear 1020 mgdl. To optimise therapy, in icupharmacy collaboration, a dosing protocol was introduced on the icu of the medical center leeuwarden, the netherlands. Vancomycin prescribing and therapeutic drug monitoring clinical guideline v6. Back to top join our foundation trust today and support our hospitals sign up today and stay up to date with the latest news and events. Vancomycin dosing for adults university health system. Vancomycin therapeutic drug monitoring vancouver coastal. Vancomycin dosing can be challenging and much debate exists as to how to employ it both safely and effectively. For indications refer to the trusts antibiotic guideline. An effective treatment option for grampositive peritonitis in peritoneal dialysis published.
Pdf evaluation of a protocol for vancomycin administration. If parenteral vancomycin therapy is desired, use an intravenous preparation of vancomycin and consult the package insert accompanying that preparation. This guideline may be varied, withdrawn or replaced at any time. Vancomycin levels should be repeated until there are two consecutive levels within target range. Lhs pharmacy vancomycin adult dosing protocol patients excluded from this protocol. Antimicrobial use guidelines university of wisconsin hospital. This help order will remain on the mar other vancomycin doses will still be visible if you want to manage offprotocol not finalized. Conduct surveillance for hocdi for inpatient pediatric.
Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillinresistant staphylococcus aureus infections in adults and children catherine liu,1 arnold bayer,3,5 sara e. Administration guidelines 1,3 reconstitute 500 mg vancomycin with sterile water 10ml per vial. As you will see, in addition to antibiotic recommendations. Vancomycin protocol rqhr free download as pdf file. This consensus revision evaluates the current scientific data and controversies associated with vancomycin dosing and serum concentration monitoring for serious methicillinresistant s.
In rare cases, these germs can sometimes cause infections, such as a blood infection, that may need to be treated. Pharmacy vancomycin dosing guideline summary revised 72014 guidelines for dosing and monitoring patients on vancomycin consult responsibilities. Vancomycin dosing in obesity idaho society of health system. Aug 31, 2010 treatment algorithm to reduce the use of vancomycin in adults with blood stream infection bacteremia the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Vancomycin dosing new 2019 therapuetic guideline what.
Guidelines for the use of vancomycin by continuous infusion in critical care areas introduction the efficacy of vancomycin is dependant on the time for which the serum concentration exceeds the minimum inhibitory concentration mic. Refer to appendix for weightbased dose guide no renal dysfunction and at least one of the following present. Clinical practice guidelines by the infectious diseases. Guidelines for monitoring of vancomycin serum concentrations. While subtherapeutical vancomycin serum concentration vsc is associated with increased mortality, accumulation is responsible for nephrotoxicity. Protocol for the administration of intravenous vancomycin. Initial vancomycin dosing protocol to achieve therapeutic serum concentrations in patients undergoing hemodialysis. Vancomycin dosing resources and the 5 most important. Baseline competency assessment of pharmacists prescribing and. Lukes boise and meridian vancomycin dosing guidelines for obese patients. Clinical practice guidelines for clostridium difficile. Pdf evaluation of a pharmacistdirected vancomycin dosing and. Pharmacy vancomycin dosing guideline summary revised 72014. Benefits of therapeutic drug monitoring of vancomycin.
Preface the antimicrobial use guidelines represent the expert opinion and advice of attending physicians of the university of wisconsin hospital and clinics, particularly, the infectious diseases section of the department of medicine and. Vancomycin is a glycopeptide antibiotic that has been in clinical use for nearly 50 years as a penicillin alternative to treat penicillinaseproducing strains of staphylococcus aureus. Intravenous vancomycin in adults via intermittent pulsed infusion. Current guidelines for the treatment of clostridium difficile infections cdis recommend vancomycin enemas for patients with adynamic ileus. Vancomycin is a glycopeptide antibiotic that has activity against gram positive organisms including methicillin resistant staphylococcus aureus mrsa, and some enterococcus species. High peaks are not associated with improved bactericidal effects and may be associated with. Our study aimed to estimate the efficacy of a vancomycin dosing protocol in reaching appropriate serum concentration in patients with and without kidney dysfunction. In the 2009 vancomycin dosing guidelines released by the american society of healthsystem pharmacists, the infectious diseases society of america, and the society of infectious diseases pharmacists, it was recommended that vancomycin troughs be maintained above 10 mcgml for all infections and that goals of 15 to 20 mcgml should be targeted. The vials contain vancomycin as a white powder for reconstitution. Aims to design and evaluate dosing guidelines for vancomycin based on data collected during routine use of the drug. Aug 09, 2019 vancomycin is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Vancomycin has been long considered the gold standard therapy for methicillinresistant staphylococcus aureus mrsa. Pediatric intravenous antimicrobial dosing guideline for infants and children 1 month of age approved by the antimicrobial subcommittee and the pharmacy and therapeutics committee 92016, department of pharmaceutical services for assistance in antimicrobial dosing especially in patients with renal and hepatic failure contact the.
Jun 27, 2015 administration of vancomycin in critically ill patients needs close regulation. Dailymed vancocin vancomycin hydrochloride capsule. Learn whats changed and how theyll impact you by reading our guide to the new vancomycin dosing changes here the 2009 guidelines for monitoring vancomycin levels in adult patients recommended patients maintain trough serum vancomycin concentrations of at least 10 mgl for all infections to. Vancomycin 1 vancomycin is a glycopeptide antibiotic with activity against grampositive infections such as staphylococcus including mrsa, streptococcus and enterococcus for the treatment of intravascular catheter related blood stream infection, mrsa sepsis, skin and soft tissue infections. Intracolonic vancomycin for severe clostridium difficile. This article is meant to help people identify some of the most important questions to ask when dosing vancomycin for injection. The new vancomycin dosing guidelines have been officially released. Implementation of a protocol for administration of vancomycin. Excluded patients include those receiving sled or peritoneal dialysis, patients receiving vancomycin antibiotic lock therapy, and pediatric patients. Xx xx xxxx 3 cases per patient admissions for cohcfa in pediatric patients as for adults good practice recommendation. Vancomycinresistant enterococci vre acteria, such as enterococcus, are commonly found in the bowel large intestine and generally do not cause any problems.
Reconstitute 500 mg vancomycin with sterile water 10ml per vial. Ucsfmc adult vancomycin dosing and monitoring recommendations. Due to the fact that the early use of vancomycin was associated with a number of adverse effects, including nephrotoxicity, infusionrelated toxicities and possible ototoxicity, therapeutic drug monitoring tdm of vancomycin was advocated. Heparin infusion rate should never exceed 3,900 unitshr 39 mlhr 1241 if initial dose is ordered in. Use auc to optimize vancomycin dosing pharmacy times. Methods following the observation that 66% of neonatal vancomycin trough concentrations were outside the target range, new dose guidelines were developed using a population pharmacokinetic approach. Vancomycin dosing and monitoring guidelines nb provincial health authorities antiinfective stewardship committee general comments vancomycin is a glycopeptide antibiotic with bactericidal activity it is active against gram positive bacteria, including methicillinresistant staphylococcus mrsa. Implementation of a protocol for administration of vancomycin by continuous infusion. The monitoring of vancomycin to achieve efficacious levels and avoid toxicity is usually done as trough levels. Historically, vancomycin in pediatric patients has been dosed at 40mgkgday for empiric. The draft of the revised vancomycin therapeutic guidelines by rybak et al. A summary of the outcomes with our protocol of treatment are shown in table 1. If discontinued, provider assumes responsibility for monitoring vancomycin therapy 7 confidential for discussion purposes only epic order 8 select vancomycin per pharmacy protocol. Adult antibiotic treatment guidelines by site of infection.
Pre vancomycin level if patient is not responding to therapy 4. Vancomycin enema in the treatment of clostridium difficile. Some institutions have recognized a trend of increased mics for vancomycin among. Treatment algorithm to reduce the use of vancomycin in adults. To evaluate the effectiveness of a new vancomycin dosing protocol in morbidly obese patients in achieving therapeutic trough concentrations between 10 and 20 mcgml and to determine patientspecific factors influencing the trough concentration attained. Letter evaluation of a vancomycin dosing protocol for.
Clostridium difficile colitis is associated with increased age, antibiotic usage, and hospitalization. Sometimes, enterococcus learns to defend itself from an antibiotic called. This protocol details the dosing, prescribing, monitoring and administration of intravenous vancomycin as an intermittent pulsed infusion. The vancomycin serum concentration targets of this protocol. Guidelines developed by uwhc department of pharmacy. The recommendations in this guide are meant to serve as treatment guidelines for use at michigan medicine facilities. If trough levels are 35 mgl, hold vancomycin, check a vancomycin level and scr q12h, and restart with a new vancomycin regimen when the level is within the therapeutic range. Evaluation of a new vancomycin dosing protocol in morbidly. This method has been used when rapid desensitization has failed.
Although troughonly therapeutic monitoring for vancomycin. We initiated an adjuvant intracolonic vancomycin icv enema protocol for inpatients with severe c. Oral vancomycin may be used for the treatment of antibiotic associated colitis. Recommendations for preventing the spread of vancomycin. Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity, multidisciplinary process. The ucsf adult vancomycin dosing calculator excel file for download can also be used to develop revised dosing regimens based on vancomycin levels obtained. Purpose to ensure the administration of intraperitoneal vancomycin is performed according to best practice guidelines reducing the risk of infection and ensuring patient safety 2. Intraperitoneal and subsequent intravenous vancomycin. Vancomycin protocol rqhr hemodialysis renal function. In rare cases, these germs can sometimes cause infections, such as a blood infection.
Vancomycin can also be administered as a continuous infusion, when practical, for. Empiric therapy for severe communityacquired sepsis. Slow vancomycin desensitization protocol lin method. It is important to ensure the vancomycin level was taken at the correct time i. Clinical practice guidelines for clostridium difficile infection cid 2018. Practice guidelines are systematically developed statements to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances. Pharmacokinetics and dose requirements of vancomycin in. Evaluation of a protocol for vancomycin administration in critically patients with and without kidney dysfunction. Pediatric intravenous antimicrobial dosing guideline for.
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